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Mutographs生物库:一个独特的基因组资源,用于研究世界各地的癌症

Sandra Perdomo¹, Behnoush Abedi-Ardekani¹, Ana Carolina de Carvalho¹

¹Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.

|February 7, 2024

概括

Mutographs项目建立了一个全球癌症生物存储库和基因组数据集,来自7800多例. 这个资源将促进癌症基因组流行病学和癌症原因的理解.

科学领域:

基因组流行病学基因组流行病学
癌症研究癌症研究
这是生物银行.

背景情况:

大规模的生物存储库和数据库对于促进癌症预防,检测,治疗,护理和监测至关重要.
突变镜项目解决了对全球癌症综合数据的需求.

研究的目的:

为癌症研究创建一个大规模的基因组数据集和生物存储库.
通过全基因组测序,了解八个解剖部位癌症的原因.
让基因组,暴露和临床数据公开可访问.

主要方法:

收集了来自30个国家的7,800多例癌症病例的样本和数据.
收集了大量的人口,生活方式,环境和临床信息.
在4000多个病例中进行全基因组测序.

主要成果:

建立了超过7,800例癌症病例的生物存储库和基因组数据集.
综合数据包括人口,生活方式,环境和临床信息.
对于4000多个病例,全基因组测序即将完成.

结论:

Mutographs项目为全球癌症研究提供了宝贵的遗留资源.
公开提供的数据将促进癌症基因组流行病学领域的新项目和合作.
这个倡议旨在提高对癌症原因的理解,并改善全世界的癌症结果.

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