液体恒温的神经控制在冬眠状态下在10°C以下进行
Madeleine S Junkins1, Ni Y Feng2, Lyle A Murphy3
1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Current biology : CB
|February 7, 2024
概括
冬眠中的松鼠通过激活抗尿激素途径,在 - 兴奋过渡期间保持液体平衡. 这种神经生理机制涉及下丘脑上视核 (SON) 神经元,即使在低体温下也能发挥作用.
科学领域:
- 生理学 生理学 生理学
- 神经科学是一个神经科学.
- 比较生物学的比较生物学
背景情况:
- 冬眠的十三条线地松鼠在没有水的情况下度过冬天,但液体平衡机制仍然不清楚.
- 在昏迷 (4°C) 期间,松鼠会降低新陈代谢和抗尿激素 (氨酸,血压素和催产素).
- 间隔激发 (IBAs) 暂时恢复体温,但尽管荷尔蒙水平较低,但仍能防止流体流失.
研究的目的:
- 研究冬眠期间液体恒温的机制.
- 确定抗利尿激素途径在 - 兴奋过渡过程中的作用.
- 确定在低体温下保持液体的神经生理基础.
主要方法:
- 在体内纤维摄影测量下丘脑上视核 (SON) 神经元.
- 在冬眠中的松鼠中RNA测序和c-FOS免疫组织化学.
- 监测血激素水平和体温在的兴奋周期期间.
主要成果:
- SON神经元在昏迷激发过渡的早期被激活,在显著的体温恢复之前.
- 在兴奋过程中,SON神经元的电,转录和翻译活动会增加.
- 在体温超过10°C之前,荷尔蒙释放和血水平上升,表明早期途径激活.
结论:
- 抗利尿途径对于冬眠期间的气-兴奋过渡期间的液体保留至关重要.
- 在冬眠者中,协调液体保留的神经生理机制在极低的体温下是活跃的.
- 这项研究揭示了在冬眠哺乳动物中维持液体平衡的独特适应.
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