早期食道状细胞癌的内镜下粘膜剖析:来自西方队列的长期结果
Ilse N Beaufort1,2, Charlotte N Frederiks1,2, Anouk Overwater2,1
1Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Endoscopy
|February 7, 2024
概括
在西方患者中,内镜下粘膜切割 (ESD) 对早期食道状细胞癌 (ESCC) 有效. 长期存活率很好,但发生了非治愈的切除,结果受到其他死亡原因的影响.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术内镜是指手术内镜.
背景情况:
- 内镜下粘膜切割 (ESD) 是早期食道状细胞癌 (ESCC) 的首要治疗方法.
- 对于ESCC来说,大多数关于ESD的现有数据来自亚洲人群.
- 这项研究评估了西方队列中早期ESCC的ESD的长期结果.
研究的目的:
- 在西方患者队列中评估ESD对早期ESCC的长期有效性和安全性.
- 为了确定治愈切除率,ESCC特异性生存率和ESD后的整体生存率.
- 将结果与来自亚洲研究的现有数据进行比较.
主要方法:
- 追溯队列研究,包括早期ESCC患者接受ESD治疗.
- 来自荷兰四家三级转诊医院 (2012-2017年) 的数据.
- 分析的结果包括技术成功,治愈切除率和生存概率.
主要成果:
- 在97%的患者中,ESD在技术上是成功的.
- 52%的病例实现了治愈性切除,而47%的非治愈性切除需要额外的治疗.
- 五年整体生存率为62%,ESCC特异性生存率为86%.
结论:
- 在西方人群中,ESD是早期ESCC的有效和安全治疗方法.
- 观察到大量的非治愈性切除率.
- 长期预后受到竞争的死亡原因的影响,无论治愈切除状态如何.
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