角质层酸化对于恢复皮肤屏障功能在湿疹性疾病中的重要性
1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea. choieh@yonsei.ac.kr.
Annals of dermatology
|February 7, 2024
概括
保持皮肤酸度对于健康的皮肤屏障至关重要. 酸化角层 (SC) 改善屏障功能,有利于诸如阿托皮炎 (AD) 和皮肤衰老等疾病.
科学领域:
- 皮肤病学和皮肤生理学
- 皮肤屏障的生物化学
- 障碍物恒温和pH调节的障碍物.
背景情况:
- 皮肤屏障功能取决于角层 (SC) 脂质,天然保湿因子 (NMF) 和酸性SC表面pH.
- 内源途径包括脂,费拉格林 (FLG) 降解和-质子抗载体 (NHE1) 活性维持SC酸性.
- 升高的SC pH会损害屏障功能,增加感染风险,并与新生儿,老年人和炎症皮肤有关,包括阿托皮炎 (AD).
研究的目的:
- 为了研究SC pH在皮肤屏障功能中的作用.
- 探索SC pH对AD和老化等皮肤状况的影响.
- 评估SC酸化对皮肤屏障疾病的治疗潜力.
主要方法:
- 对调节SC pH的内源途径的审查.
- 在AD和老化皮肤中分析SC pH的变化.
- 检查AD小鼠模型中SC酸化的影响和对护肤产品的影响.
主要成果:
- 酸性SC pH对于陶胺生产和酶活性至关重要;高的pH会损害屏障的完整性和恢复.
- 在AD中,减少的NMF,脂肪酸和乳酸有助于增加SC pH和蛋白酶失衡.
- 在阿尔茨海默氏症模型中,SC酸化防止了疾病的进展;在老化皮肤中,将pH值正常化改善了屏障功能.
结论:
- 保持SC酸性对于健康的皮肤屏障功能至关重要.
- 皮肤酸化对阿托皮性皮肤炎和与衰老相关的皮肤问题具有治疗效益.
- 酸性护肤和治疗可以恢复皮肤pH平衡并改善屏障完整性.
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