脂肪器官功能障碍和2型糖尿病:氧化的作用
Zahra Bahadoran1, Parvin Mirmiran2, Asghar Ghasemi3
1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
氧化 (NO·) 在脂肪组织 (AT) 功能和2型糖尿病 (T2D) 发育中起着至关重要的作用. 维持生理NO·水平是关键,因为缺乏和多余的NO·都会导致代谢功能障碍.
科学领域:
- 内分泌学 在内分泌学.
- 代谢科学 代谢科学
- 生理学 生理学 生理学
背景情况:
- 脂肪组织 (AT),最大的内分泌器官,包括皮下和内脏部分与白色和色/棕色脂肪细胞.
- 在AT中存在的功能障碍,其特点是分布不良,高,缺氧,炎症和胰岛素抵抗,与2型糖尿病 (T2D) 有关.
研究的目的:
- 阐明氧化 (NO·) 在脂肪组织 (功能障碍) 中对2型糖尿病 (T2D) 发展的作用.
- 探索NO·生物可用性和特定酶的合成对代谢恒温的影响.
主要方法:
- 审查和突出NO·在脂肪组织内调节脂质和葡萄糖平衡中的确定的作用.
- 讨论NO·在代谢调节中的双重作用,受内皮NO·合成酶 (eNOS) 和可诱导NO·合成酶 (iNOS) 的影响.
- 分析改变NO·信号的后果,包括降低生物可用性和过度的iNOS衍生的NO·,对AT和全身代谢.
主要成果:
- 由eNOS产生的生理水平的NO·,对于维持AT中的脂质和葡萄糖平衡至关重要.
- 降低NO·生物可用性 (由于eNOS活动减少或NO·清理) 会损害新陈代谢功能.
- 来自iNOS的过度NO,通常是由AT中缺氧和炎症引起的,可以导致反应性物种的形成和代谢功能障碍.
结论:
- NO·信号是脂肪组织功能及其对T2D的贡献的关键决定因素.
- 旨在通过增强eNOS活性和抑制eNOS来使AT中的NO·水平正常化的治疗策略,对T2D治疗有希望.
- 准脂肪组织中的NO·通路代表了新型T2D治疗的潜在途径.
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