通过apoptotic caspases的气体皮质的裂变触发了激光灭,限制了Hydra中的细菌殖民
Shuxin Li1, Xiaoyang Lu1, Xiuqing Lin1
1State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, East China University of Science and Technology, Shanghai, 200237, China.
Developmental and comparative immunology
|February 7, 2024
概括
功能性Gasdermin E (GSDME) 同类物首次出现在类动物中,揭示了火的古老起源. 这项研究表明,GSDME依赖性热是Hydra.的保存宿主防御机制.
科学领域:
- 进化生物学是进化的生物学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 加斯德明 (GSDM) 蛋白质执行热,这是一个关键的炎症性细胞死亡过程.
- 功能性GSDM,特别是GSDME的进化起源在很大程度上是未知的.
- GSDM对于宿主防御病原体,炎症和癌症至关重要.
研究的目的:
- 为了研究功能性GSDME的进化起源.
- 为了确定是否apoptotic caspase-GSDME级联在原始动物中得到保存.
- 探索GSDME依赖性火死在鱼中的作用.
主要方法:
- 生物信息分析用于识别鱼类中的GSDME同类物.
- 在体外切割试验中,使用 cnidarian caspases 和 GSDME.进行了切割试验.
- 在Hydra的体内实验中,评估热诱导及其对感染的影响.
主要成果:
- 在类动物中发现了功能性GSDME同类物,这表明它们的起源很古老.
- 科尼达的GSDME同类物具有保存的卡斯帕斯裂解部位.
- 液体GSDME (HyGSDME) 被Hydra caspases分裂,诱导热,从而增强损伤并限制细菌负载.
- 这种热会保护Hydra免受病原体入侵.
结论:
- GSDME依赖性热是一种古老的宿主防御机制,可以追溯到类动物.
- 这些发现提供了GSDM和热的进化历史的见解.
- 这项研究在原始元动物中建立了卡斯巴酶活性,GSDME和火灭症之间的功能联系.
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