从Hypericum ascyron Linn中重新排列了两种具有中度神经保护作用的乙基醇
Shuo Wang1, Yuyu Shao1, Lingran Tian1
1Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
Fitoterapia
|February 7, 2024
概括
两个新的化合物,hyperascone A和B,从Hypericum ascyron Linn.中分离出来. 这些,以及已知的化合物,显示出对抗细胞损伤的显著神经保护作用.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 神经药理学神经药理学
背景情况:
- 希佩里克姆 (hypericum) 和阿斯基隆 (ascyron) 林. 是一种具有潜在药用特性的植物物种.
- 多环多烯酸酸醇 (PPAP) 是一种具有多种生物活性的自然产品.
- 神经退行性疾病对健康构成重大挑战,需要寻找新型治疗剂.
研究的目的:
- 从Hypericum ascyron Linn.中分离和描述新的化合物.
- 评估隔离化合物对特定细胞损伤模型的神经保护潜力.
主要方法:
- 植物化学研究涉及隔离和净化技术.
- 使用先进的光谱方法 (HRMS,NMR,ECD) 阐明结构.
- 在体外测试以评估SH-SY5Y细胞中对MPP+诱导的毒性和微质激活的神经保护.
主要成果:
- 隔离了两个新的重新排列的PPAP,hyperascone A和B,以及三种已知的化合物 (tomoeone A,1,3,5-trihydroxy-6-O-prenylxanthone,3,7-dihydroxy-1,6-dimethoxyxanthone).
- 对所有五种孤立化合物的完整结构确定.
- 证明所有五种化合物的神经保护作用对SH-SY5Y细胞中MPP+诱导和微质激活诱导的损伤.
结论:
- 希佩里克姆 (hypericum) 和阿斯基隆 (ascyron) 林. 是一种新型生物活性化合物的来源.
- 超级体A和B代表了一类新的重新排列的PPAP.
- 隔离的化合物具有显著的神经保护性,这表明神经退行性疾病的潜在治疗应用.
关键词:
这种植物名为Hypericum ascyron.聚环多乙烯酸化乙烯基氨基醇 (Polycyclic polyprenylated acylphloroglucinols) 是一种多环多乙烯酸的化合物.在SH-SY5Y细胞中.克桑的使用方法 Xanthones更多相关视频
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