饮食中的蛋白质来源,遗传学和心血管疾病发病率
Suying Qian1, Mengyao Fu2, Liyuan Han3
1Department of Hematology and Oncology, Ningbo No.2 Hospital, Ningbo 315010, Zhejiang, China.
Journal of affective disorders
|February 7, 2024
概括
摄入植物蛋白与降低心血管疾病 (CVD) 风险有关,而动物蛋白与风险增加有关. 用植物蛋白代替动物蛋白可以减少心血管疾病的发生率.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 遗传学 是一个遗传学.
背景情况:
- 饮食中的蛋白质摄入量和来源是心血管疾病 (CVD) 风险的潜在调节者.
- 遗传倾向可能会影响饮食和心血管疾病之间的关系.
- 了解这些关联对于公共卫生建议至关重要.
研究的目的:
- 调查饮食中的蛋白质量/来源与心血管疾病发病率之间的相关性.
- 检查遗传敏感性在饮食与心血管疾病关系中的作用.
- 评估用植物蛋白代替动物蛋白对心血管疾病风险的影响.
主要方法:
- 对98,224名英国参与者的前性分析.
- 饮食中的蛋白质摄入量通过两次24小时的召回评估.
- 使用多变量调整的考克斯回归,受限制的立方线和遗传风险得分.
主要成果:
- 在心血管疾病风险和植物蛋白能量百分比 (p=0.005) 之间观察到J形关联.
- 更高的植物和全蛋白摄入量与降低心血管疾病风险相关.
- 增加动物蛋白摄入量与较高的冠状动脉疾病 (CAD) 风险和中风发病率有关.
结论:
- 更高的植物,整个和坚果蛋白质消费与较低的心血管疾病风险有关.
- 增加动物蛋白摄入量与增加CAD风险有关.
- 用植物蛋白能量取代5%的动物蛋白能量,可将心血管疾病风险降低5%.
相关概念视频
Proteins: Dietary Sources and Requirements
443
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
443
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Human Genetics
570
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
570
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Incomplete Dominance
22.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.6K


