导出安全摄入乙烯甘醇的考虑因素
Ari S Lewis1, Steven R Boomhower2, Charlotte M Marsh1
1Gradient, Boston, MA, 02108, USA.
概括
烯糖醇 (PG) 的饮食暴露可能超过可接受的每日摄入量 (ADI). 由于物种间具有相似的毒性作用,建议修订每天ADI为62.5mg/kg,支持增加PG消费的安全边际.
科学领域:
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
- 风险评估 风险评估
背景情况:
- 二醇 (PG) 在食品和其他产品中广泛使用.
- 通过饮食接触PG可以接近或超过目前的每日可接受摄入量 (ADI) 25 mg/kg bw-day.
- 目前的ADI使用的是100的累积不确定性因子.
研究的目的:
- 评估二醇 (PG) 的毒理学数据.
- 为了确定是否可以将化学特异性调整因子 (CSAF) 应用于PG的ADI.
- 根据有毒动力学反应的物种相似性,建议对PG进行修订的ADI.
主要方法:
- 审查可用的毒理学研究和关于PG的人类数据.
- 确定PG毒性的可信作用方式 (MoA).
- 评估物种间毒动力学差异对PG的关键作用.
主要成果:
- 确定了一种可信的MoA,涉及血清PG度增加,高度和血液溶解变化.
- MOA支持CSAF为1的物种间毒动力学差异.
- 总不确定性因子可以从100降低到40.
结论:
- 在毒力学反应中的物种相似性支持PG的CSAF为1.
- 对于PG的ADI可以从25增加到62.5mg/kg bw-day.
- 修订后的ADI适用于儿童和成人,反映出潜在的更安全的消费水平.
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