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工程哺乳动物细胞生长动态用于生物制造

Mauro Torres1, Dewi Mcconnaughie1, Samia Akhtar1

  • 1Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, UK; Department of Chemical Engineering, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, UK.

Metabolic engineering
|February 7, 2024
PubMed
概括

这项研究对哺乳动物细胞进行了改造,用于生物制药制造中的精确生长控制. 合成生物学工具被用来创建可调节的"气体和制动"系统来调节细胞生长动态.

关键词:
生物制药产品 生物制药产品克里斯普尔-Cas9是什么意思细胞工程是细胞工程.基因电路的基因.控制核扩散的方法

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Most vertebrate cells grow in vitro attached to a substrate as a monolayer, called adherent cultures. The flasks and plates used to grow cells are chemically treated to facilitate cell attachment. However, a few cell types, such as hematopoietic cells, can grow in a suspension. In contrast to adherent cultures, suspension cultures can grow in non-treated cultureware using magnetic stirrers or spinner flasks to agitate the culture media
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