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Updated: Jul 4, 2025

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
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针对PDK/PDH轴,通过基于结构的虚拟查与体外和体内实验来逆转代谢异常

Jianda Yue1, Jiawei Xu1, Yekui Yin1

  • 1The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410081, China; Peptide and Small Molecule Drug R&D Plateform, Furong Laboratory, Hunan Normal University, Changsha 410081, Hunan, China; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha 410081, China.

International journal of biological macromolecules
|February 7, 2024
PubMed
概括

研究人员发现了一种小分子g25,通过准pyruvate dehydrogenase kinase (PDK) 来激活pyruvate dehydrogenase (PDH). 这种分子通过改善能量代谢和减少脂肪,显示出治疗肥胖和糖尿病等代谢障碍的潜力.

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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