臭氧和动脉硬之间的关联是否可以通过鱼油补充剂来改变?
Wenxing Han1, Jin Zhang1, Zhihu Xu1
1Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
Environmental research
|February 7, 2024
概括
暴露于臭氧会增加动脉硬度,但食用鱼油可以提供保护. 像甘油三等生物标志物部分调解了这种臭氧 - 动脉硬度的联系,这表明了潜在的干预目标.
科学领域:
- 环境健康 环境健康
- 心血管疾病流行病学
- 营养流行病学 营养流行病学
背景情况:
- 动脉硬 (AS) 是心血管疾病的一个关键预测因素.
- 臭氧暴露对AS的影响和鱼油的修饰作用仍未得到充分研究.
- 研究臭氧与AS关系中的生物标志物调解至关重要.
研究的目的:
- 为了检查臭氧暴露与动脉硬之间的关联.
- 调查甘油三,阿波利波蛋白B/阿波利波蛋白A和非高密度脂蛋白胆固醇的调解作用.
- 为了确定鱼油消费是否会改变臭氧-AS关系.
主要方法:
- 利用了来自英国生物库的95,699名中年和老年人的数据.
- 通过社区多尺度空气质量 (CMAQ) 模型评估臭氧暴露.
- 采用双重强大的方法和分层分析来评估协会和调解.
主要成果:
- 臭氧暴露与动脉硬度 (ASI) 的增加显著相关.
- 鱼油消费与较低的动脉硬度有关.
- 三甲酸甘油,ApoB/ApoA和非HDL-C介导了10.90%-18.30%的臭氧与AS的关联.
- 鱼油摄入量显著减弱了臭氧与AS的关系.
结论:
- 臭氧暴露与较高的动脉硬性有关,而鱼油显示有保护作用.
- 生物标志物部分调解了臭氧暴露和动脉硬之间的关系.
- 鱼油消费可能会减轻臭氧对一般人群动脉硬性的不良影响.
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