双极A,一个含有未描述的5/8/5/7碳骨架的sesterterpenoid从双极可能
Yong Shen1, Chunmei Chen1, Ziming Zhao1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
鉴定了Bipolaris maydis中五种新的ophiobolin衍生型的sesterterpenoid,它们具有新的结构和显著的抗扩散和抗菌活性. 这些发现为天然产品在控制食品病原体方面提供了潜力.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 化学生物学 化学生物学
背景情况:
- 植物病原菌如Bipolaris maydis是生物活性二次代谢产物的来源.
- 类类的一类,表现出多样化的生物活动.
- 奥菲奥博林是一种具有复杂结构的sesterterpenoids的子类.
研究的目的:
- 从Bipolaris中分离和表征新的ophiobolin衍生型的sesterterpenoids可能会出现.
- 阐明这些新型化合物的结构和绝对配置.
- 评估分离化合物的抗扩散和抗微生物活性.
主要方法:
- 使用色谱技术分离化合物.
- 通过综合光谱分析 (HRESIMS,NMR) 阐明结构.
- 使用电子圆二元论 (ECD) 计算和单晶X射线衍射来确定绝对配置.
主要成果:
- 他们分离了五种新的ophiobolin衍生型的sesterterpenoids (Bipoladiens A-E,1-5) 和一种已知的化合物 (bipolaricin R,6).
- 化合物1具有一个新的四环5/8/5/7化碳骨架.
- 复合物2拥有罕见的多循环圈环系统.
- 化合物6证明了对A549细胞的强烈抗增殖和亡诱导.
- 化合物5和6显示抗微生物活性对细菌大麦,金黄色葡萄球菌和 Staphylococcus epidermidis.
结论:
- 这项研究扩大了ophiobolin-sesterterpenoids的化学多样性.
- 已识别的化合物显示出有前途的抗扩散和抗微生物特性.
- 来自Bipolaris的天然产品可能没有控制食物传播病原体的潜力.
更多相关视频
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
11:04Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
相关概念视频
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group...
Five-Membered Heterocyclic Aromatic Compounds: Overview
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
Aromatic Hydrocarbon Anions: Structural Overview
Due to the absence of continuous...
Structure of Conjugated Dienes
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
