在大脑内出血后,感觉运动皮质中素乙化的表观遗传修饰
Taichi Nishio1, Takahiro Inoue1, Yasuyuki Takamatsu2
1Graduate School of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo, 060-0812, Japan.
Biomedical research (Tokyo, Japan)
|February 7, 2024
概括
脑内出血 (ICH) 改变了大脑中的表观遗传调节,影响了感觉运动功能. 这项研究发现,在ICH后的老鼠中,基因乙化增加和基因表达改变,影响神经可塑性.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 表观遗传修饰,如基因组乙化,在中风后的神经可塑性中发挥作用.
- 脑内出血 (ICH) 可能导致长期的感觉运动缺陷.
研究的目的:
- 调查ICH对与神经元可塑性相关的基因表达和基因乙化的影响.
- 评估这些表观遗传变化与感觉运动功能恢复之间的相关性.
主要方法:
- 威斯特老鼠接受了刻板的ICH手术或假手术.
- 用脚故障和气测试来评估运动功能.
- 在感官运动皮层中分析了基因组乙化水平和神经营养因子 (IGF-1,BDNF) 的mRNA表达.
主要成果:
- 与虚假对照相比,ICH大鼠表现出较差的感觉运动功能.
- ICH显著增加了素H3和H4乙化在两侧感觉运动皮层的ipsilateral和contralateral.
- 在ICH后的ipsilateral皮质中,IGF-1 mRNA表达被上调,而BDNF mRNA表达被下调.
结论:
- ICH在感觉运动皮质中诱导了广泛的组织乙烯化变化.
- 这些表观遗传变化为神经可塑性相关的基因创造了改性分子环境.
- 这项研究强调了表观遗传学在中风后功能恢复中的作用.
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