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由单边尿路阻塞引起的纤维化的发病和治疗

Qi Yan Nan^1,2, Shang Guo Piao¹, Ji Zhe Jin¹

¹Department of Nephrology, Yanbian University Hospital, Yanji, China.

Kidney research and clinical practice

|February 7, 2024

概括

单侧尿路阻塞 (UUO) 在动物模型纤维化. 了解其复杂的分子通路,包括氨酸-血管素系统 (RAS) 和氧化应激,是开发性痕新疗法的关键.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
病理学病理学病理学
分子生物学分子生物学

背景情况:

纤维化是渐进性病的常见终点.
单侧尿路阻塞 (UUO) 是用于研究纤维化的可再生动物模型.
UUO模型表现出管间炎症,细胞外矩阵积累和纤维化.

研究的目的:

在UUO模型中审查纤维化背后的分子机制.
突出目前和新兴的治疗策略,脏痕.
为提供UUO诱导纤维化病原体的概述.

主要方法:

对纤维化和UUO模型研究的文献综述.
对参与纤维化病原发生的分子途径的分析.
对脏痕的治疗干预措施的检查.

主要成果:

纤维化病原发生涉及复杂的,多因素的途径.
关键的途径包括氨酸- ангиотензин系统 (RAS) 激活,氧化应激和炎症反应.
新兴疗法包括RAS抑制剂,抗氧化剂和抗糖尿病药物 (SGLT2和DPP-4抑制剂).

结论:

对于了解纤维化机制来说,UUO模型非常有价值.
目前治疗脏痕的疗法有效性有限.
针对特定的分子途径为新的治疗策略提供了潜力.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.自自是一种自的过程.细胞内膜网膜应激压力是什么线粒体中的线粒体.氧化应激是一种氧化应激.单边尿路阻塞单边尿路阻塞

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