奥克萨利普拉丁相关的消化障碍:混合方法研究研究
Ciarán Kenny1, Julie Regan2, Lucy Balding3
1Department of Clinical Speech and Language Studies, University of Dublin Trinity College, Dublin, Ireland ckenny9@tcd.ie.
BMJ supportive & palliative care
|February 7, 2024
概括
奥克萨利普拉丁化疗与不寻常的吞问题有关,包括温度敏感性和喉感觉. 这些非典型的消化不良症状需要进一步研究,以帮助患者的营养和享受饭菜.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床药房 临床药房
背景情况:
- 缺食症是癌症患者常见的担忧.
- 化疗剂可以引起各种副作用,影响生活质量.
- 了解特定的与药物相关的毒性对于支持性护理至关重要.
研究的目的:
- 为了调查接受氧沙治疗的患者所经历的非典型消化不良症状.
- 为了确定氧沙治疗与特定的吞困难之间的关联.
主要方法:
- 一项涉及73名成年癌症患者的观察性研究.
- 通过半结构面试和口腔健康评估工具收集的数据.
- 面试答复的内容分析和统计关联的Fischer的精确测试.
主要成果:
- 奥克萨利普拉丁治疗与不寻常的消化不良症状相关:热/冷玻尿酸问题 (p=0.01),麻醉 (p=0.001),喉 (p=0.035).
- 在67%的参与者中,化疗开始之前出现了吞问题.
- 缺食症症状与粘膜炎没有联系 (p=0.165).
结论:
- 在接受氧沙丁治疗的患者中,非典型的消化障碍很可能归因于化疗.
- 除了寒冷,热和碳酸玻尿酸可以触发这些患者的消化不良.
- 需要对缺食症的症状和触发因素进行进一步的研究,以预防营养不良并改善患者的福祉.
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