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使用双传染系统来预测hOCT2/hMATE1-介导的脏药物相互作用

Letícia Salvador Vieira1, Joanne Wang2

  • 1Department of Pharmaceutics, University of Washington, Seattle, Washington.

Drug metabolism and disposition: the biological fate of chemicals
|February 7, 2024
PubMed
概括

预测涉及人类有机阴离子载体2 (hOCT2) 和人类多种药物和毒素挤出蛋白 (hMATEs) 的药物相互作用 (DDI) 是一个挑战. 使用双转移细胞和IC50,flux的新流量试验通过考虑细胞内抑制剂的访问,准确地预测脏DDIs.

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