[编程细胞死亡的临床特征-1 抑制剂相关的低细胞性炎]
1Department of Endocrinology, Affiliated Hospital of Hebei University, Baoding 071030, China.
Zhonghua nei ke za zhi
|February 7, 2024
概括
编程细胞死亡-1 (PD-1) 抑制剂相关的低细胞性炎往往在晚些时候出现胃肠道症状和疲劳. 这种状况主要影响上腺,有些病例也表现出甲状腺功能低下和下腺功能低下,通常没有明显的垂体成像变化.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 编程细胞死亡-1 (PD-1) 抑制剂在癌症治疗中至关重要.
- 与免疫相关的不良事件 (irAEs) 与PD-1抑制剂是常见的.
- 低体质炎是一种已知的影响 pituitary 腺体的 irAE.
研究的目的:
- 为了研究由PD-1抑制剂诱导的低血炎的临床特征.
- 为了提高对这种特定免疫相关不良事件的理解.
- 分析PD-1抑制剂相关性低血压炎的临床表现和预后.
主要方法:
- 回溯案例系列设计.
- 从2020年1月至2023年5月期间接受治疗的患者的临床数据分析.
- 包括被诊断患有PD-1抑制剂相关的低体质炎的患者.
主要成果:
- 分析了15例病例,主要是男性 (13/15).
- 常见的症状包括胃肠道问题 (14/15) 和疲劳 (12/15).
- 所有患者都表现出二次上腺皮质缺陷;一些人患有甲状腺功能低下症 (4/15) 和腺功能低下症 (2/15).
- 在大多数情况下,垂体MRI显示出极少或没有异常 (11/15).
结论:
- 与PD-1抑制剂相关的低性炎往往在治疗后期发生.
- 胃肠道症状和疲劳是主要的投诉.
- 上皮质功能不充分是主要的内分泌功能障碍,有可能导致甲状腺功能低下和下腺功能低下.
- 下垂体成像通常没有显著的变化,强调了临床和荷尔蒙评估的重要性.
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