通过皮肤挥发性概况预测时间年龄
Melissa Finnegan1, Shane Fitzgerald1, Romain Duroux2
1School of Chemical Sciences, Insight SFI Research Centre for Data Analytics, National Centre for Sensor Research, Dublin City University, Dublin D09 V209, Ireland.
Journal of the American Society for Mass Spectrometry
|February 7, 2024
概括
皮肤挥发性化合物可以以68%的准确度预测一个人的年龄. 这项研究分析了60名健康个体的皮肤排放,确定了潜在的健康诊断的关键年龄相关的挥发性化合物.
科学领域:
- 挥发力学是一种挥发力学.
- 生物化学 生化学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤挥发性排放提供了对代谢活动和皮肤微生物群的非侵入性见解.
- 以前的小型研究表明,特定的挥发性化合物与衰老之间存在相关性.
- 了解皮肤挥发性物质与年龄相关的变化对于开发新的健康诊断至关重要.
研究的目的:
- 为了研究皮肤挥发性化合物与健康队列中的时间年龄之间的相关性.
- 为了确定特定的挥发性化合物,这些化合物随着年龄的增长而发生显著变化.
- 评估皮肤挥发物的预测能力,以估计年龄.
主要方法:
- 采集和分析了60名健康参与者的皮肤挥发性排放,使用头部空间-固体相微提取 (HS-SPME) 和气色谱-质谱法 (GC-MS).
- 确定了18种合适的挥发性化合物,并根据性别影响对它们进行了分类.
- 采用多重线性回归 (MLR) 分析以模型年龄,使用显著波动量和性别.
主要成果:
- 六种挥发性化合物 (内源性和外源性) 的含量随参与者的年龄显著变化 (p < 0.1).
- 皮肤挥发性概况表现出对年龄有很强的预测能力,解释了68%的差异.
- 皮肤挥发物对年龄的预测能力超过了其他生化指标,如皮肤表面pH值和水含量.
结论:
- 皮肤挥发性排放受到衰老的显著影响,反映了内源和外源化合物来源.
- 皮肤挥发物为预测年龄提供了强大的,非侵入性的生物标志物,其性能优于传统的生物化学标志物.
- 这项研究支持开发基于 volatilomics 的诊断,以评估健康的"基线"皮肤的挥发性概况.
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