一种病理评分系统,用于预测肝细胞癌破裂患者的术后预后
Feng Xia1, Qiao Zhang2, Guobing Xia3
1Department of Hepatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Asian journal of surgery
|February 7, 2024
概括
一个新的评分系统准确地预测了手术后破裂性肝细胞癌 (rHCC) 患者的生存率. 基于病理因素的MSE得分,将患者分为低风险,中等风险和高风险组,以便更好地预测预后.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 手术瘤学手术瘤学
背景情况:
- 破裂性肝细胞癌 (rHCC) 病理因素的预后准确性尚不清楚.
- 在肝切除术后预测rHCC患者的结果需要强大的工具.
- 需要新的评分系统来改善rHCC中的风险分层.
研究的目的:
- 开发和验证一种使用病理因素预测rHCC患者术后存活率的新型评分系统.
- 为了确定MSE得分在分层rHCC患者中的准确性.
- 在rHCC中创建和验证用于预测整体存活率 (OS) 和无复发存活率 (RFS) 的nomograms.
主要方法:
- 使用单变量和多变量考克斯回归的MSE (微血管入侵-卫星焦点-埃德蒙森·施泰纳) 评分的发展.
- 在MSE得分中包括微血管入侵,卫星焦点和差异化等级.
- 使用ROC和校准分析的培训和验证队列验证MSE得分和相关的诺米克.
主要成果:
- MSE得分与OS和RFS有显著的相关性,使得患者分层明显 (P<0.05).
- 包括MSE得分,巴塞罗那诊所肝癌阶段和α-fetoprotein的诺摩图表显示出良好的区别 (C指数>0.760).
- 在训练和验证队伍中,Nomograms显示出优异的校准,用于预测OS和RFS.
结论:
- 临床MSE得分准确地预测了肝切除术后切除性破裂性肝细胞癌患者的OS和RFS.
- 开发出来的诺姆图为rHCC的预后评估提供了可靠的工具.
- 病理因素对于预测接受手术的rHCC患者的结果至关重要.
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