关于食品蛋白诱导肠球炎综合征 (FPIES) 的共识指南的当前和未来观点
Sara Anvari1, Melanie A Ruffner2, Anna Nowak-Wegrzyn3
1Division of Immunology, Allergy and Retrovirology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA.
概括
食物蛋白诱导肠球炎综合征 (FPIES) 是一种非IgE介导的食物过敏. 最近的证据凸显了成人FPIES和新的触发因素,需要更新所有年龄组的诊断和管理指南.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 食物蛋白诱导肠球炎综合征 (FPIES) 是一种非IgE介导的食物过敏.
- 它的病理生理学还不太清楚.
- 2017年国际FPIES指南改善了诊断和管理.
研究的目的:
- 自2017年以来审查FPIES诊断和管理的临床证据.
- 确定指导方针发展的领域,包括成人发病FPIES和非典型呈现.
- 为解决儿童和成人FPIES患者更新方案的需要.
主要方法:
- 在2017年国际FPIES指南之后发表的研究的文献综述.
- 关注有关FPIES表型,触发因素和管理策略的新证据.
- 对成人发病FPIES和非典型病例的新兴数据的分析.
主要成果:
- 新的证据已经出现在成人发病的FPIES,多样化的表型和新的食物触发因素上.
- 目前的指导方针可能需要改进,以涵盖更广泛的患者群体和表现.
- 对于儿科和成人FPIES患者,需要更新食物挑战协议.
结论:
- 最近的研究需要对2017年FPIES指南进行更新.
- 准则应包括成人FPIES,多种表型和新触发因素的发现.
- 量身定制的诊断和管理协议对于所有FPIES患者群体至关重要.
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