相关实验视频
Updated: Jul 4, 2025

05:38
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
76
儿科患者患有炎症性肠病的皮肤表现
Mohsen Afarideh1, Katherine Bartoletta2, Megha M Tollefson1,2
1Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Pediatric dermatology
|February 7, 2024
概括
皮肤病在患有炎症性肠病 (IBD) 的儿童中很常见,感染最常见. 克罗恩氏病 (CD) 患者表现出更多的角性炎和围问题,而严重的IBD与牛皮和皮肤质相关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 皮肤病学 皮肤病学
- 炎症性肠道疾病研究研究
背景情况:
- 关于儿科炎性肠病 (IBD) 皮肤病变的患病率和严重程度相关性的数据有限.
- 之前的研究主要集中在成人IBD患者身上,在了解儿科IBD相关皮肤病方面存在知识差距.
- 这项研究解决了有关IBD儿童皮肤表现的综合数据的需求.
研究的目的:
- 确定IBD儿童皮肤表现的流行率.
- 调查儿科患者的IBD严重程度和特定皮肤病变之间的相关性.
- 为了比较儿童中克罗恩病 (CD) 和性结肠炎 (UC) 之间的皮肤疾病的发生率.
主要方法:
- 在1999年至2017年期间,在梅奥诊所诊断出IBD的528名儿科患者 (≤18岁) 的回顾性图表审查.
- 使用奇方位/费舍尔精确测试 (p≤0.05) 进行统计分析,以比较CD和UC队列之间的结果.
- 纳入标准要求患者至少有一个皮肤病诊断记录.
主要成果:
- 在425名皮肤病诊断IBD患者中,感染最常见 (42.8%).
- (30.8%),湿疹 (15.8%) 和围皮肤标签 (14.6%) 是普遍存在的非传染性疾病.
- 患有CD的儿童患角性炎,角性炎 (KP) 和围并发症的比率更高 (p<0.05).
- 在UC患者中,真菌性皮肤感染更常见 (p=0.017).
- 严重的IBD与周围囊/,牛皮和皮肤质 (PG) 的患病率增加相关 (p<0.05).
结论:
- 皮肤病,特别是感染,在儿科IBD中非常普遍.
- 与UC患者相比,患有CD的儿童更容易患上角性炎,KP和围皮肤问题.
- 周围疾病,牛皮和PG显著与更严重的儿科IBD有关.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
Inflammatory Bowel Disease I: Ulcerative Colitis
186
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
186
Chronic Bowel Disorders: Introduction
450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Inflammatory Bowel Disease IV: Pharmacological Management
127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
127
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
166
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166

