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Updated: Jul 4, 2025

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ASPSCR1-TFE3通过在六度VCP/p97周围组织增强器循环来重新编程转录

Amir Pozner1,2,3, Li Li1,2,3, Shiv Prakash Verma1,2,3

  • 1Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.

Nature communications
|February 7, 2024
PubMed
概括

研究人员发现,VCP/p97对ASPSCR1::TFE3基蛋白至关重要,该基蛋白驱动罕见癌症,如膜软部肉瘤 (ASPS) 和Xp11重组细胞癌 (RCC). 向VCP为这些具有挑战性的疾病提供了一个有希望的新治疗策略.

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