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抑制性中间不确定的区域通路通过抑制质形神经元来驱动探索性行为

Sandeep Sharma^1,2, Cecilia A Badenhorst^1,2, Donovan M Ashby^1,3

¹Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.

Nature communications

|February 7, 2024

概括

中间不确定的区域 (mZI) 通过调节状核 (CnF) 神经元来影响探索行为. 这项研究揭示了一种新的神经回路,调节了依赖上下文的运动和防御行为.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学

背景情况:

已知形核 (CnF) 调节运动,主要是启动运动和控制速度.
最近的研究强调了CnF在运动功能中的作用的上下文依赖性.
在CnF中的Glutamatergic神经元,表达膀性谷氨酸转运体2 (vGLUT2),与上下文依赖的速度控制和防御行为有关.

研究的目的:

调查从中部不确定区域 (mZI) 到CnF的预测.
阐明mZI玛-氨基黄油酸 (GABA) 神经元在调节CnF vGLUT2神经元和探索性行为中的作用.
了解神经机制,是运动的依赖上下文调节的基础.

主要方法:

在雄性小鼠中进行纤维光度记录以监测神经活动.
特定的神经元群体的光遗传激活和抑制 (mZI GABAergic神经元,mZI-CnF投影神经元,CnF vGLUT2神经元).
逆行标签用于识别神经元投射.

主要成果:

在探索期内,mZI GABA神经元的活性增加.
激活mZIGABAergic神经元导致CnF神经元中的尖端发生减少.
激活mZI-CnF GABAergic投射或抑制CnF vGLUT2神经元可以促进探索性行为.
该mZI-CnF电路动态调节CnF vGLUT2神经元活动.

结论:

一个新的mZI-CnFGABAergic电路调节探索行为.
这些发现表明CnF vGLUT2神经元的上下文依赖调节.
这个电路通过动态神经调制在塑造探索性行为方面发挥着重要作用.

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