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Updated: Jul 4, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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通过寡合化促进的NLRP3激活的结构基础.

Xiaodi Yu1, Rosalie E Matico2, Robyn Miller2

  • 1Johnson & Johnson Innovation Medicine, Spring House, PA, 19044, USA. xyu6@its.jnj.com.

Nature communications
|February 7, 2024
PubMed
概括

含有NACHT,氨酸丰富的重复和pyrin域的蛋白3 (NLRP3) 经历了结构转变为开放的八合体,揭示了其激活机制. 这种寡合合作激活对于人类疾病中炎症细胞组合至关重要.

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