阿斯科布酸可以防止超重和肥胖个体的压力诱导的高凝血
Helena N M Rocha1,2,3, Larissa L Velasco1,2, Gabriel M S Batista1,2
1Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, RJ, 24.020-150, Brazil.
亚酸 (AA) 补充剂有助于超重/肥胖男性在精神压力 (MS) 期间保持静血平衡. 这项研究表明,AA的使用可以防止血液凝结因子的负面变化,并改善应对压力的酸盐水平.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 精神压力 (MS) 可以破坏静血平衡,特别是在超重/肥胖的成年人中.
- 超重/肥胖与血栓事件的风险增加有关.
- 亚酸 (AA) 是一种抗氧化剂,具有潜在的静血调节性质.
研究的目的:
- 为了研究亚酸 (AA) 给药对超重/肥胖男性对精神压力 (MS) 的静血反应的影响.
- 为了确定AA是否可以减轻凝血参数中压力诱导的变化.
主要方法:
- 一项随机对照试验,涉及14名超重/肥胖男性.
- 参与者在接受安慰剂 (PL) 或3g酸 (AA) 后接受了Stroop颜色词压力任务.
- 血液样本被分析为前热血素时间 (PT),激活的部分血栓形成时间 (aPTT),纤维素素,血小板衍生微粒 (PMV) 和酸盐水平在基线,压力期间和后压力.
主要成果:
- 在安慰剂治疗中,多发性硬化诱导了PT,PT-INR,aPTT和纤维素原的显著下降,表明了促凝剂的转变.
- 阿斯科布酸的使用防止了这些压力诱导的PT,PT-INR和纤维素因子的下降.
- 与安慰剂相比,AA在压力期间显著增加了酸盐水平,这表明氧化的生物可用性有所改善.
结论:
- 在超重和肥胖男性中,阿斯科布酸有效地防止了由精神压力引起的静血平衡损害.
- 服用AA改善了对压力的化物反应,这表明其血静保护作用的潜在机制.
- 这些发现凸显了 Askorbic 酸在管理风险人群中与压力相关的静血失调方面的潜在作用.
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