在间歇性囊炎/膀疼痛综合征中氧化应激的机制
Ashu Mohammad1, Mallory A Laboulaye2, Chen Shenhar1
1Department of Urology, Stanford University School of Medicine, Palo Alto, CA, USA.
Nature reviews. Urology
|February 7, 2024
概括
间歇性囊炎/膀疼痛综合征 (IC/BPS) 涉及盆腔疼痛和尿道问题. 氧化应激有助于IC / BPS病原体,突出了改善患者结果的潜在治疗目标.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 病理生理学 病理生理学
- 分子生物学分子生物学
背景情况:
- 间歇性囊炎/膀疼痛综合征 (IC/BPS) 与盆腔疼痛,尿急,频率和夜尿有关.
- 目前对IC/BPS病理生理学的理解是有限的,提出的机制包括炎症,自身免疫问题,泌尿器功能障碍和GAG屏障受损.
- 现有的治疗方法产生不满意的反应,可能是由于疾病异质性和非向方法.
研究的目的:
- 探索氧化应激在IC/BPS病变发生中的作用.
- 确定将活性氧物种与IC/BPS联系起来的分子机制.
- 倡导开发新的研究模型来研究治疗点.
主要方法:
- 关于IC/BPS病原和氧化应激现有的文献的审查.
- 分析涉及IC/BPS的分子通路,包括激酶信号传递,感觉受体,巨细胞激活,尿路细胞失调和昼夜节律.
- 讨论对新型实验模型的需求.
主要成果:
- 通过反应性氧物种 (ROS) 的氧化应激,与IC/BPS中的膀功能受损有关.
- ROS与IC/BPS中的关键途径有关,例如激酶信号传递,恶性感知,巨细胞激活,泌尿器功能障碍和昼夜节律扰乱.
- 需要进一步的研究来阐明氧化应激的确切作用.
结论:
- 氧化应激是IC/BPS病变发生的一个重要因素.
- 了解ROS和特定分子通路之间的联系对于开发向疗法至关重要.
- 开发先进的研究模型对于验证针对IC/BPS中氧化应激的治疗策略至关重要.
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