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相关概念视频

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

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相关实验视频

Updated: Jun 13, 2026

Non-invasive 3D-Visualization with Sub-micron Resolution Using Synchrotron-X-ray-tomography
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移动中的人类中耳:3D可视化和量化使用动态同步子基于X射线成像的3D可视化和量化.

Margaux Schmeltz1, Aleksandra Ivanovic2,3,4, Christian M Schlepütz2

  • 1Paul Scherrer Institute, Swiss Light Source, Villigen, Switzerland. margaux.schmeltz@psi.ch.

Communications biology
|February 7, 2024
PubMed
概括

这项研究可视化了人类中耳骨振动,使用先进的X射线显微断层学. 它量化了声音传输期间的骨运动,为耳机械提供了新的见解.

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Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

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科学领域:

  • 生物医学工程 生物医学工程
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 医疗成像医学成像

背景情况:

  • 描述中耳骨振动对于临床研究至关重要.
  • 在深深的中耳中测量微米尺度的运动在技术上是具有挑战性的.

研究的目的:

  • 开发和应用一种新的成像技术,用于在体内可视化中耳骨运动.
  • 在声学刺激过程中量化分析鼓膜和骨链的三维动态.

主要方法:

  • 基于动态同步仪的X射线相位对比微图学被用于声学刺激的人类骨.
  • 一个后门算法和高通量管道处理数据以解决快速微动 (128 Hz).
  • 在七个健康的活体人类骨中,骨的刚性身体运动被量化.

主要成果:

  • 该研究实现了完整的人类鼓膜和运动中的骨链的3D可视化.
  • 骨链的临床相关区域被3D追踪.
  • 骨位移的幅度被计算为两个不同的声学刺激.

结论:

  • 动态同步射线X射线微图扫描能够详细可视化和量化中耳骨振动.
  • 这种技术克服了研究中耳机械的先前局限性.
  • 这些发现为了解正常和潜在的病理性骨功能提供了基础.