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Updated: Jul 4, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Published on: May 9, 2025

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自然发生的T细胞突变增强了人工T细胞疗法

Julie Garcia1,2,3, Jay Daniels1,4,5,3, Yujin Lee4,5

  • 1Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.

Nature
|February 7, 2024
PubMed
概括

科学家发现了来自T细胞癌的基因融合 CARD11-PIK3R3, 增强了采用T细胞疗法的持久性和抗瘤效果. 通过利用自然发生的突变来改善癌症治疗,

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