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相关概念视频

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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相关实验视频

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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
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在各种癌症患者中进行了临床前研究和第一个人体成像[18F]FAP-2286,并与2-[18F]FDG PET/CT进行比较

Lifang Liu1,2, Jiawei Zhong3, Ziqi Zhang3

  • 1Nuclear Medicine Department, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

European journal of nuclear medicine and molecular imaging
|February 7, 2024
PubMed
概括
此摘要是机器生成的。

一种新型的标记物[18F]FAP-2286,在临床前和临床癌症成像中显示出纤维细胞激活蛋白 (FAP) 的高特异性和吸收率. 这种FAP向剂在某些非急性癌症中显示出作为2-[18F]FDG PET的替代品的希望.

关键词:
在 Al18F-PET/CT/CT 中使用.临床转换 临床转换在FAP-2286中使用.纤维细胞激活蛋白-α 的活性.

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科学领域:

  • 放射化学和核医学 放射化学和核医学
  • 在瘤学瘤学.
  • 分子成像学分子成像学

背景情况:

  • 纤维细胞激活蛋白 (FAP) 是一种跨膜蛋白酶,在许多固体瘤中的癌症相关纤维细胞 (CAF) 上高度表达.
  • 在正常组织中,FAP的表达明显较低或不存在,这使其成为癌症成像和治疗的有吸引力的目标.
  • 目前的成像剂具有局限性,需要开发新的高性能追踪器.

研究的目的:

  • 开发和描述一个新的FAP特定的正子发射断层扫描 (PET) 追踪器,[18F]FAP-2286.
  • 为了评估[18F]FAP-2286的临床前性能,与现有的药物比如[18F]FAPI-42和[68Ga]Ga-FAP-2286.
  • 评估[18F]FAP-2286在患有各种癌症的患者中的临床实用性,将其与2-[18F]FDG PET进行比较.

主要方法:

  • [18F]FAP-2286是在良好制造实践 (GMP) 条件下合成的.
  • 实验室试验包括使用HT-1080hFAP细胞进行细胞吸收,竞争性结合亲和力,内化和排泄研究.
  • 在体内研究涉及瘤携带小鼠模型中的PET成像和生物分布,以及15名癌症患者的试点临床研究.

主要成果:

  • [18F]FAP-2286实现了30.53±5.20%的放射性标记产量,其放射性化学纯度高于97%.
  • 在体外,标记物表现出特定的吸收,高内部化和低排放量.
  • PET成像显示,在临床前模型和癌症患者中,瘤迅速吸收和令人满意的保留.

结论:

  • [18F]FAP-2286表现出卓越的成像特性,包括快速和高的目标吸收和持续的保留.
  • 追踪器显示出作为早期或延迟阶段PET成像的有效工具的潜力.
  • [18F]FAP-2286可能成为对2-[18F]FDG不热衷的成像癌症的有价值的替代品,特别是那些低葡萄糖代谢的癌症.