双糖酸盐突变酶预测心肌功能障碍和败血症的不良结果:一项观察性队列研究
Long Huang1, Xincai Wang2, Bawei Huang3
1Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provicial Hospital, Fuzhou, China.
BMC infectious diseases
|February 7, 2024
概括
血清双糖酸突变酶 (BPGM) 的升高表明心脏损伤,并预测败血症患者的预后不佳. 较高的BPGM水平与死亡风险增加和败血症中心肌损伤相关.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 临界护理医学 临界护理医学
背景情况:
- 败血症导致炎症,心脏损伤和死亡率增加.
- 糖解路径与败血症引起的心脏损伤有关.
- 双糖酸酶突变酶 (BPGM) 是一个关键的糖溶性中间体.
研究的目的:
- 研究血清BPGM在评估败血症心脏损伤中的作用.
- 确定BPGM在败血症患者预后不良的预测值.
- 评估BPGM作为毒引起的心肌损伤的潜在生物标志物.
主要方法:
- 对85名败血症患者进行前性研究.
- 在入学时测量的血清BPGM水平;根据BPGM状态分组的患者.
- 临床,心声学参数和结果的分析;进行了卡普兰-梅尔,后勤回归和ROC曲线分析.
主要成果:
- 非幸存者与幸存者的血清BPGM水平显著更高 (p < 0.001).
- BPGM阳性与较短的28天生存时间相关 (p < 0.001).
- 血清BPGM和降低的LVEF-Simpson是28天死亡率的独立风险因素;BPGM与心肌功能障碍标志物相关.
结论:
- 血清BPGM水平作为心肌损伤在败血症的监测指标.
- 高水平的BPGM标志着二次性心肌损伤和不良结果.
- BPGM是败血症引起的心肌损伤和死亡率的有价值预测因素.
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