在冷解胚胎移植后怀孕的单胞胎双胞胎的孕产妇和产周风险:一项回顾性队列研究
Jing Lin1, Kai Zhang2, Fenglu Wu3
1Center for Reproductive Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Journal of ovarian research
|February 7, 2024
概括
通过冷解胚胎移植 (FET) 怀孕的单胞胎双胞胎面临更高的新生儿死亡风险. 加强产前监测对于这些高风险怀孕至关重要.
科学领域:
- 生殖医学和围产学.
- 辅助生殖技术 辅助生殖技术
- 新生儿结局的结果.
背景情况:
- 冷解胚胎移植 (FET) 是一种常见的辅助生殖技术.
- 单胞胎双胞胎 (MZT) 可以在FET后出现,带来独特的围产期风险.
- 了解这些风险对于优化孕产妇和新生儿护理至关重要.
研究的目的:
- 调查与通过FET怀孕的MZT怀孕相关的孕产妇和产周风险.
- 为了比较FET后MZT和双胞胎双胞胎 (DZT) 之间的结果.
- 确定导致MZT新生儿不良后果的特定风险因素.
主要方法:
- 通过FET (2007-2021) 怀孕的双胞胎出生的回顾性审查.
- 使用后勤回归和双重可靠估计的MZT与DZT结果的比较.
- 分析包括新生儿死亡,高血压疾病,妊娠糖尿病,早产,低出生体重和出生缺陷.
主要成果:
- 通过FET怀孕的MZT怀孕显示新生儿死亡风险显著增加 (OR:4.95).
- MZT与更高的胎儿膜破裂率,早产,低出生体重和妊娠年龄相对较小的早产率有关.
- 在MZT中,早产和低出生体重部分介导了新生儿死亡风险的增加.
结论:
- 通过FET怀孕的MZT与高新生儿死亡率有关.
- 早产和低出生体重的风险增加有助于MZT新生儿死亡率.
- 建议对通过FET怀孕的MZT怀孕进行全面的产前监测.
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