使用热酶功能化纳米催化剂进行癌症治疗的氨基酸剥夺的选择性增强细胞毒性
Xiuhui Tang1, Lijuan Zhang2, Mingwang Huang1
1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.
Journal of nanobiotechnology
|February 7, 2024
概括
这项研究引入了一种新的热酶策略,使用金纳米棒进行精确的近红外触发光热疗法,用于乳腺癌. 这种方法增强了酶的递送和活性,以有效,安全的瘤治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 酶疗法 酶疗法 酶疗法
背景情况:
- 酶疗法在癌症治疗方面表现有前途,但在控制酶活性,稳定性和在体温下有效性方面面临挑战.
- 热稳定酶在生理条件下经常表现出低活性,限制了它们的独立治疗应用.
研究的目的:
- 开发一种新的热酶调节策略,用于精确,近红外 (NIR) 触发的乳腺癌光热治疗.
- 创建一个纳米平台,以有效地传递和控制治疗酶的激活.
主要方法:
- 从热友细菌中选和利用热酶.
- 合热酶与氨酸 (HA) 功能化黄金纳米棒 (GNRs) 进行增强的交付.
- 使用局部化的NIR激光器进行远程,按需的酶激活和光热疗法 (PTT).
主要成果:
- 开发的纳米催化剂证明了增强的细胞吸收和快速的酶活性.
- 该策略通过温度隔离的酶活性来最大限度地减少非目标毒性影响,从而提供了生物安全.
- 由NIR触发的激活有效诱导氨基酸剥夺,细胞亡,细胞循环停止,并抑制瘤迁移和入侵.
结论:
- 为酶疗法建立了一个精确的,遥控的,非侵入性的,高效的,生物安全的纳米平台.
- 这种方法为个性化治疗策略提供了理由,并促进了高精度酶药物的开发.
更多相关视频
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
6.0K
10:46A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
3.6K
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K