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Updated: Jul 4, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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两种高度相似的二合成酶的表征和工程揭示了一个区域选择性的反开关

Dan Ye1, Yi-Zhen Shao1, Wen-Rui Li1

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People's Republic of China.

Angewandte Chemie (International ed. in English)
|February 8, 2024
PubMed
概括

研究人员在控制产品多样性的聚二烯合成酶 (STPSs) 中确定了关键活性部位残留物. 突变这些残留物切换了酶功能,使得各种碳化合物骨架的新型STPS的合理设计成为可能.

关键词:
功能互转换的功能互转换.胚芽细胞 A 胚芽细胞 A 胚芽细胞 A分子基的分子基础.区域选择性反化 区域选择性反化六二烯合成酶的使用方法

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