系统性硬化症中的炎症性关节炎:它的流行病学,关联和发病率
Eric Schwender1, Dylan Hansen2, Wendy Stevens2
1Royal College of Surgeons, Dublin, Ireland.
Arthritis care & research
|February 8, 2024
概括
炎症性关节炎 (IA) 影响了三分之一的全身性硬化症 (SSc) 患者,特别是那些患有扩散性疾病的患者. 这种情况与生活质量下降和身体残疾增加有关.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特征是纤维化和血管异常.
- 炎症性关节炎 (IA) 是一个已知的,但尚未完全理解的,SSc.内的表现.
- 了解IA的患病率和影响对于全面的SSc患者管理至关重要.
研究的目的:
- 研究系统性硬化症 (SSc) 患者炎症性关节炎 (IA) 的流行病学.
- 在SSc队列中确定IA的临床和血清学关联.
- 评估IA对SSc.身体功能和与健康相关的生活质量 (HRQoL) 的影响.
主要方法:
- 在澳大利亚硬化硬化症队列研究中招募SSc患者的前景.
- 对IA的临床诊断是基于突炎的存在.
- 对关联的后勤回归分析;患者报告的功能影响的结果措施.
主要成果:
- 在33.3%的SSc患者中观察到IA,随访时间中位数为4.3年.
- IA与扩散的SSc,肌肉骨问题,肌肉炎和sicca症状相关;与肺动脉高血压负相关.
- IA与更低的HRQoL和更大的身体残疾有关;在IA患者中,反周期性素抗体更为频繁.
结论:
- 炎症性关节炎是系统性硬化症的常见表现,特别是在扩散性疾病中.
- 艾亚显著导致SSc患者的健康相关生活质量和身体残疾降低.
- 对SSc中的IA有效管理策略进行进一步的研究是有必要的.
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