大基因组分析揭示了ADHD患者肠道微生物群的差异
Ning Wang1,2,3,4, Haibin Wang5, Yu Bai5
1Peking University Sixth Hospital, Beijing, China.
Journal of attention disorders
|February 8, 2024
概括
与健康个体相比,患有注意力缺陷/多动障碍 (ADHD) 的儿童的肠道微生物群组成显著不同. 这些发现表明,肠道细菌可能在ADHD发育中发挥作用,并可能提供潜在的生物标志物.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 注意缺陷/多动障碍 (ADHD) 具有强烈的遗传成分,但环境因素也会对其发展产生影响.
- 新兴研究表明肠道微生物群与精神疾病之间存在联系.
研究的目的:
- 研究被诊断患有多动症的儿童和青少年肠道微生物群的特征组成.
- 识别特定的细菌种群,使ADHD患者与健康对照区分开来.
主要方法:
- 招募了47名没有服用过药物的儿童和患有多动症的青少年和60名健康对照人群 (HCs).
- 采用枪元基因组学来分析肠道微生物群结构.
- 在ADHD和HC组之间比较细菌分类组的组成.
主要成果:
- 在ADHD和HC组之间观察到阿尔法多样性的显著差异 (辛普森和香农指数) (分别为p=0.025和p=0.049).
- 贝塔多样性指数 (欧几里德,布雷-库蒂斯,JSD距离) 也显示出显著的差异 (p < 2.2e-16).
- 确定了9种细菌物种作为这些群体之间的关键歧视因素.
结论:
- 与健康对照组相比,ADHD患者的肠道微生物群组成发生了显著的变化.
- 这些变化可能成为ADHD的潜在诊断生物标志物.
- 对ADHD的肠-大脑轴的进一步研究是有必要的.
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