在一项试验中进行研究,以评估随机对照试验的招聘和保留策略:从PROMETHEUS研究计划中吸取的教训
Adwoa Parker1, Catherine Arundel1, Laura Clark1
1York Trials Unit, Department of Health Sciences, University of York, York, UK.
Health technology assessment (Winchester, England)
|February 8, 2024
概括
在临床试验中的研究 (SWAT) 改善了临床试验中的参与者招募和保留. "促进在审判中使用研究"计划成功资助和支持了42个特种部队,大大扩大了有效策略的证据基础.
科学领域:
- 临床试验方法论 临床试验方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 随机对照试验在招募和留住参与者方面面临挑战.
- 试验内研究 (SWAT) 对于评估改善这些过程的策略至关重要.
- 需要更多的SWAT进行,以加强证据基础.
研究的目的:
- 促进执行至少25个专注于招聘或保留策略的SWAT.
- 分享经验和经验教训,从提供促进在试验中使用研究的程序中学习.
- 为了指导未来进行随机SWAT的努力.
主要方法:
- 建立了一个由10个临床试验单位和1个初级保健研究中心组成的网络.
- 在患者和公众参与下,确定并优先考虑招聘和保留策略.
- 为主机试验团队提供资金和支持,以进行SWAT.
- 在多个试验中测试了协调SWAT的可行性.
主要成果:
- 在12个临床试验单位资助了42个特种部队,超过了目标.
- 证明了预先通知,使用笔和个性化短信等策略的有效性.
- 在Cochrane审查中对招聘 (18%的增加) 和保留 (79%的增加) 策略的证据基础做出了重大贡献.
- 成功实施协调和因数式SWAT设计.
结论:
- "促进在试验中使用研究"计划大大增强了招聘和保留策略的证据.
- 当提供足够的资金和支持时,主机试验团队有效地实施了SWAT.
- 未来的研究应该专注于解决证据差距,增加SWAT采用,并将研究结果转化为实践.
关键词:
数据准确性 数据准确性嵌入式试验 嵌入式试验基于证据的医学.基于证据的医学/标准.人类人类.方法论 方法论 方法论患者的保留能力患者的选择.实践指南 实践指南作为主题/标准的实践指南.随机对照试验作为主题.随机的受控试验 随机的受控试验研究设计研究设计研究参与者研究参与者研究人员研究人员研究对象 研究对象样本大小 样本大小试验中的研究 (SWAT)更多相关视频
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