SARS-CoV-2和慢性髓性白血病:一个系统性审查
Elrazi A Ali1, Anas Al-Sadi2, Qusai Al-Maharmeh3
1Internal Medicine Department, Interfaith Medical Center/One Brooklyn Health, Brooklyn, NY, United States.
Frontiers in medicine
|February 8, 2024
概括
这项系统性审查发现,患有慢性髓性白血病 (CML) 和COVID-19 (严重急性呼吸系统综合征冠状病毒2) 的患者在接种疫苗后的死亡率较低. 需要进一步的研究来了解COVID-19
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,这是一个流行病,对免疫功能低下的人来说风险更高.
- 慢性髓性白血病 (CML) 患者面临治疗效果和COVID-19结果的不确定性,包括疫苗的疗效.
研究的目的:
- 系统地审查COVID-19对慢性髓性白血病 (CML) 患者的影响.
- 评估感染SARS-CoV-2的CML患者的死亡率和血栓事件风险.
- 在COVID-19大流行期间评估疫苗接种对CML患者结果的影响.
主要方法:
- 根据PRISMA标准进行了系统审查.
- 在PubMed,SCOPUS和谷歌学者中搜索了SARS-CoV-2感染的CML患者 (年龄大于18岁) 的研究.
- 包括截至2023年4月20日发表的回顾性,前性研究,评论,案例系列和案例报告.
主要成果:
- 分析了33篇文章和682名患有COVID-19的CML患者.
- 疫苗接种前的死亡率为11% (30/277),疫苗接种后的死亡率为4% (15/405).
- 没有报告发生血栓事件;疫苗接种后ICU入院率下降.
结论:
- 由于数据有限,CML患者的COVID-19结局需要进一步调查.
- 与其他血液性恶性瘤相比,患有COVID-19的CML患者没有显著增加死亡风险.
- 疫苗接种似乎与COVID-19的CML患者的改善结果和降低死亡率有关.
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