皮肤上生长因子受体的皮肤毒性:从2013年到2023年的综合药监测研究
Hanyu Dan1, Qiang Jiang1, Xiangnan Jia1
1Medical Information Analysis Laboratory, College of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.
Frontiers in medicine
|February 8, 2024
概括
表皮生长因子受体抑制剂 (EGFRI) 可能导致皮肤问题,特别是在老年患者中. 这项研究分析了FDA的数据,发现皮疹和皮肤干燥是EGFRIs中常见的副作用.
科学领域:
- 药物监督 药物监督 药物监督
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 皮肤毒性是与表皮生长因子受体抑制剂 (EGFRI) 相关的常见不良事件.
- 了解这些皮肤毒性的范围对于患者的管理和治疗坚持至关重要.
- EGFRI是用于癌症治疗的药物类别,需要仔细监测副作用.
研究的目的:
- 系统地调查EGFRI和皮肤毒性之间的关联.
- 评估不同EGFRI诱导的皮肤不良事件的多样性.
- 为了确定特定的EGFRI和引起关注的皮肤反应.
主要方法:
- 从2013年1月到2023年3月使用了FDA不良事件报告系统 (FAERS) 数据库.
- 使用不成比例分析,包括报告几率比率 (ROR),信息组件 (IC),比例报告比率 (PRR) 和千平方 (χ2).
- 分析了29559个记录的皮肤不良事件.
主要成果:
- 在EGFRI和皮肤毒性之间发现了显著的相关性,特别是在老年患者 (≥65岁).
- 埃尔洛提尼布与皮肤不良事件比例最高 (39.72%) 相关.
- 皮疹,皮肤干燥和是最经常报告的首选术语. 在所有分析的EGFRIs中,始终检测到皮疹,皮肤病变和形皮肤炎的信号.
结论:
- EGFRI与一系列皮肤毒性有关,在老年人群中具有显著的流行率.
- 建议采用个性化治疗策略,考虑EGFRI的具体情况和潜在的皮肤反应.
- 持续的药物监测对于管理EGFRI诱导的皮肤不良事件至关重要.
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