一条可扩展的途径,以四元功能化的AgCl合性抗微生物抑制食物致病细菌和生物膜
Diellza Bajrami1, Syed Imdadul Hossain2,3, Alexia Barbarossa4
1Institute of Analytical and Bioanalytical Chemistry, Ulm University, Albert Einstein-Allee 11, 89081, Ulm, Germany.
Heliyon
|February 8, 2024
概括
这项研究提出了一种可扩展的方法,用于生产化银/四元化合物 (AgCl/QAC) 纳米抗菌剂. 这些绿色,稳定的纳米颗粒表现出强大的抗菌和抗菌膜活性,对抗食源性病原体,非常适合活性食品包装.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 食品科学 食品科学 食品科学
背景情况:
- 开发有效的抗微生物药物对于食品安全至关重要.
- 现有的生产抗菌纳米颗粒的方法可能是昂贵和复杂的.
- 需要为食品应用提供绿色,稳定和可扩展的抗微生物解决方案.
研究的目的:
- 开发一种多功能,可扩展,快速和强大的战略,用于生产AgCl/QAC体纳米抗菌剂 (NAMs).
- 评估这些NAM对食源性致病细菌的抗微生物和抗菌膜疗效.
- 探索它们在活性食品包装系统中的潜在应用.
主要方法:
- 一种简单的银度计定位类似的方法被调整为可扩展的生产使用环静电.
- 使用UV-Vis,X射线光电子谱学,FTIR,TEM,SAED和DLS进行纳米聚合物 (NC) 的表征.
- 测试抗菌和抗菌膜对格拉姆阳性和格拉姆阴性食物传播细菌的影响.
主要成果:
- 成功生产出稳定,成本效益高,可复制的AgCl/QAC合性NAM.
- 已证明具有显著的抗菌和抗菌膜活性,可以对抗*黄金葡萄球菌*,*单细胞菌菌*,*大肠杆菌*和*假菌*.
- 阳性 ζ-潜在与增强的抗微生物活性和体稳定性相关.
结论:
- AgCl / QAC NAMs提供了一个有前途的绿色和多功能抗微生物解决方案.
- 开发的生产策略具有可扩展性,适合大规模制造.
- 这些NAM表现出强大的长期细菌静止和抗菌膜效应,使它们成为活性食品包装的理想选择.
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