在养优质IgG质量的母乳的子子中转移免疫力
Luca Turini1, Bindi Francesca2, Vernaccini Matilde2
1Department of Agricultural, Food and Environmental Sciences, University of Pisa, Via Del Borghetto 80, 56124, Pisa, Italy.
Heliyon
|February 8, 2024
概括
在评估子子的被动免疫力时,这项研究发现血清总蛋白 (TP) 测量与免疫球蛋白G (IgG) 水平有很好的相关性. 这些发现允许对年轻马匹的IgG进行可靠估计.
科学领域:
- 兽医免疫学 兽医免疫学
- 马类新生儿护理 马类新生儿护理
背景情况:
- 免疫的被动转移对于小的生存至关重要.
- 与马和驴相比,子子的被动免疫力数据有限.
研究的目的:
- 评估不同测量血清总蛋白 (TP) 和子子免疫球蛋白G (IgG) 的方法之间的相关性.
- 建立用于估计血清IgG度的方法,使用TP在子子.
主要方法:
- 在不同时间点 (出生至48小时) 从6只子子收集了30个样本.
- 分析样本使用血清辐射免疫扩散 (SRID) 检测IgG,以及电泳,折射计和TP的生物法.
- 评估了SRID IgG和TP测量之间的相关性.
主要成果:
- 从出生到6小时,血清IgG度显著增加.
- 对于TP的折射计和酸盐方法,随着时间的推移都显示出显著的差异.
- 在SRID IgG和酸盐TP之间发现了强烈的相关性 (r=0.69);与折射计 (r=0.44) 和电泳 (r=0.39) 有良好的相关性.
结论:
- 所有经过测试的方法都可以估计子子的被动免疫力.
- 通过TP折射计和生物TP值,可以使用特定方程可靠地估计生命前48小时的血清IgG度.
更多相关视频
05:27Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
Published on: January 26, 2019
23.6K
08:37Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
16.6K
相关概念视频
Development of Immunocompetence
307
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
307
Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
Active versus Passive Immunity
643
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
643
Immunological Memory
614
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
614
