在老年人中,COVID-19疫苗的犹与皮质体积较低有关
Fardin Nabizadeh1,2,
1Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Neurology letters
|February 8, 2024
概括
对COVID-19疫苗犹不决的老年人表现出较小的额头和带大脑区域. 这一神经生物学发现将大脑结构与接种疫苗和健康行为联系起来.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 对于COVID-19疫苗的犹是疫苗接种计划的一个重要障碍.
- 以前的研究将疫苗犹与较低的认知表现联系在一起.
- 疫苗犹的神经生物学基础,特别是大脑结构模式,仍未得到充分探索.
研究的目的:
- 调查大脑结构特征 (皮层和皮下体积) 与老年人COVID-19疫苗犹之间的关联.
- 为了探索老年人疫苗犹的神经生物学基础.
主要方法:
- 利用来自阿尔茨海默病神经成像计划 (ADNI) 数据库的221名健康老年人 (平均年龄63.7±6.1) 的数据.
- 将受试者分为疫苗犹 (VH,n=87) 和疫苗接受 (VA,n=134) 组.
- 在VH和VA组之间比较区域大脑体积 (皮层和皮层下).
主要成果:
- 在VA和VH组之间没有发现认知状态 (MMSE,MoCA,ADAS-cog,RAVLT) 的显著差异.
- 接种疫苗的受试者与未接种疫苗的受试者相比,左侧轨道,左侧前中心旋转,右尾部前带状肌,右侧峡状肌的体积显著增加.
- 在其他皮层和皮下区域没有观察到显著的体积差异.
结论:
- 拥有较小额头和带带状大脑区域的老年人更容易产生COVID-19疫苗犹.
- 这些发现表明,特定的皮质大脑结构与健康保护行为 (如疫苗接种) 之间存在联系.
- 了解这些神经生物学相关性可以为解决老龄化人口疫苗犹问题的策略提供信息.
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