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双功能瘤向生物探针用于光异症

Hae Sang Park^1,2, Shinya Yokomizo¹, Haoran Wang¹

¹Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Biomaterials research

|February 8, 2024

概括

研究人员开发了一种新的近红外 (NIR) 生物探针,用于头部和部状细胞癌 (HNSCC). 这种有针对性的探针可以同时进行成像和治疗,提供更安全,更有效的癌症治疗方法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

接近红外线 (NIR) 的光疗剂可提供非侵入性成像和治疗头部和部状细胞癌 (HNSCC).
激光照射激活的有针对性的NIR光体可以通过光动力学和光热疗法选择性地根除癌细胞.
存在对具有瘤特异向和有效光疗效的NIR生物样本的需求,而不会损害健康组织.

研究的目的:

设计一种针对瘤的双功能NIR生物探针,用于HNSCC向和光异常.
评估探测器在激光照射时产生热量和反应性氧物种 (ROS) 的能力.
评估工程生物试验的体内疗效,生物分布和清除.

主要方法:

循环氨酸 - 甘氨酸 - 酸 (cRGD) 基因的生物结合,与一个ZW800-PEG (Zwitterionic Polymethine NIR Fluorophore) 的生物结合.
在808nm激光照射后在体外对细胞毒性影响,热量和ROS生成的评估.
在FaDu异种移植小鼠模型中对HNSCC的体内评估,包括成像,生物分布和清除研究.

主要成果:

在cRGD-ZW800-PEG生物试验中,在小鼠的静脉注射后4小时内,迅速准瘤.
在激光照射后,生物探针诱导了协同光热和光动力学效应,在瘤中选择性地产生热和ROS.
健康的周围组织没有受到影响,未结合的生物样本通过排泄被清除.

结论:

开发的有针对性的生物探针有效地利用光疗法来治疗HNSCC.
这种方法为更安全,更有效的癌症治疗提供了一个有希望的范式.
该研究强调了针对性癌症治疗策略的实质性进展.

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