穿孔动脉疾病中风后不良预后的预测因素
Linghua Song1, Xiaoli Lou1, Wenhao Han1
1Suzhou Dushu Lake Hospital, Suzhou, Jiangsu, China.
Frontiers in neurology
|February 8, 2024
概括
衰老,国家卫生研究院中风量表 (NIHSS) 较高的得分和中性粒细胞与淋巴细胞比率 (NLR) 的增加是穿孔动脉疾病 (PAD) 中风患者不良结果的关键预测因素. 作为预测PAD预后的生物标志物,NLR显示出潜在的潜力.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 生物标志物 生物标志物
背景情况:
- 穿孔动脉疾病 (PAD) 是缺血性中风的一个重要亚型.
- 了解PAD预后的风险因素对于患者管理至关重要.
研究的目的:
- 为了确定与不良预后相关的独立风险因素,在被诊断为因PAD而患上中风的患者中.
- 评估PAD结果的基线特征和炎症标志物的预测价值.
主要方法:
- 分析了181名患有PAD中风的患者队列.
- 在90天后,使用修改的兰金尺度 (mRS) 评估预后.
- 后勤回归和ROC分析确定了不利结果的预测因素 (mRS 3-6).
主要成果:
- 48名 (26.5%) 患者出现不良预后.
- 不良预后的独立预测因素包括晚年 (OR=1.076),较高的NIHSS得分 (OR=2.930),以及高的中性粒细胞与淋巴细胞比率 (NLR) (OR=3.028).
- 一种多因素诊断模型显示出高精度 (AUC=0.956).
结论:
- 增加的年龄,NIHSS得分和基线NLR是PAD患者预后不良的独立风险因素.
- 在PAD中预测中风预后时,NLR可能作为一个有价值的生物指标.
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