COVID-19:不是血栓性疾病,而是血栓炎症性疾病
Shu He1,2, Margareta Blombäck1,2, Håkan Wallén1
1Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Upsala journal of medical sciences
|February 8, 2024
概括
冠状病毒疾病2019 (COVID-19) 是一种血栓炎症性疾病,而不仅仅是血栓性疾病. SARS-CoV-2 感染会影响静血系统,导致血小板激活和血小板激活.
科学领域:
- * 血液学和免疫学
- * 传染病 传染病
- * 病理生理学 病理生理学
背景情况:
- *2019年冠状病毒病 (COVID-19) 虽然不再是全球紧急情况,但由于血栓性并发症,它仍然是一个重要的健康风险.
- *之前的研究表明,COVID-19基本上是一种血栓性疾病.
- *了解对静血系统的全部影响对于管理长期风险至关重要.
研究的目的:
- *为了重申COVID-19是一种血栓性疾病的假设.
- *全面评估SARS-CoV-2对整个静血系统的影响.
- * 为了阐明COVID-19的血栓炎性病原体.
主要方法:
- * 关于COVID-19和静血系统的广泛文献综述.
- *分析追踪COVID-19病变发生过程中涉及的蛋白质和细胞的反应过程的数据.
- * 评估病毒入侵,炎症,内皮损伤,免疫反应和血栓事件.
主要成果:
- *SARS-CoV-2感染增强了血栓生成,由血抗凝剂调节.
- * 纤维素素水平升高,血小板激活,VWF/ADAMTS-13不平衡,D-二次体增加有助于"纤维解质关闭".
- *COVID-19涉及ACE2依赖的病毒入侵,炎症,内皮损伤和导致血栓形成的免疫反应.
结论:
- *COVID-19的特征是显著的静血系统异常,包括增强的凝血和血小板激活.
- *这种情况表现为"纤维解质关闭"的表型,增加了血栓形成的风险.
- *由于炎症和凝血病之间的相互作用,COVID-19应被归类为血栓炎症性疾病.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
698
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
698
Disorders of Hemostasis
911
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
911
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Inflammation
53.4K
Overview
53.4K
Extrinsic and Intrinsic Pathways of Hemostasis
7.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.7K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K


