带有生物膜的核心/外纳米纤维支架:一个有前途的伤口合剂候选人
El-Refaie Kenawy1, Mohammed S A El-Moaty1, Mamdooh Ghoneum2,3
1Polymer Research Group, Chemistry Department, Faculty of Science, Tanta University Tanta 31527 Egypt ekenawy@yahoo.com.
RSC advances
|February 8, 2024
概括
这项研究表明,Biobran增强了纳米纤维支架,用于伤口愈合. 该生物活性物质改善了支架特性和细胞活力,表明作为多功能伤口带的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术纳米技术
背景情况:
- 生物布兰是一种具有潜在伤口愈合特性的生物活性物质.
- 纳米纤维支架为药物输送和组织再生提供了有希望的平台.
- 将生物活性化合物集成到支架中对于先进的伤口包裹至关重要.
研究的目的:
- 调查Biobran在改善伤口愈合方面的有效性.
- 探索Biobran对通过同轴电制造的核心/外纳米纤维支架的性能的影响.
- 评估Biobran装载的支架作为多功能伤口带的潜力.
主要方法:
- 核心/外纳米纤维支架的制造使用不同度的聚乙烯 (PCL) 和聚乙醇 (PVA).
- 包括形态 (SEM,TEM),化学结构 (FTIR),结晶性 (XRD),热稳定性 (TGA,DSC),机械性能 (应力-应变),水利性 (WCA) 和水吸收在内的支架属性的全面表征.
- 使用WISH细胞进行Biobran释放动力学,细胞毒性 (MTT试验) 和细胞增殖 (伤口伤试验,青排除) 的体外评估.
主要成果:
- 生物膜的结合导致了更光滑,更紧的脚手架形态,改变了聚合物相互作用和结晶性.
- 脚手架的特性,如抗拉强度,破裂时的延长,热稳定性和水友性,都受到Biobran的积极影响,这种影响取决于度.
- 实现了最佳的孔隙性,吸水率和水蒸气传递率 (WVTR) 用于伤口愈合. 生物布兰表现出双相释放,随着持续递送的度而下降.
- 细胞活力测定表明Biobran对WISH细胞的剂量依赖的积极作用,与改善的支架物理化学特性有关.
结论:
- 装有生物布朗的核心/外纳米纤维支架显示出增强的物理化学特性,有利于伤口愈合.
- 从这些支架中控制和持续释放Biobran可以支持细胞活力和增殖.
- 这些发现凸显了Biobran集成的纳米纤维支架作为先进的多功能伤口带的巨大潜力.
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