增长激素与儿童睡眠之间的复杂关系:见解,差异和影响
Marco Zaffanello1, Angelo Pietrobelli1, Paolo Cavarzere1
1Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
Frontiers in endocrinology
|February 8, 2024
概括
儿童生长激素缺乏 (GHD) 对睡眠产生负面影响. 虽然生长激素 (GH) 治疗可能对一些人有好处,但需要更多的研究来了解GHD.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 睡眠医学 睡眠医学
- 发展生物学 发展生物学
背景情况:
- 增长激素 (GH) 对于生长和发育至关重要,分泌主要发生在深度睡眠期间.
- 生长激素缺乏症 (GHD) 的特征是没有其他综合征特征的GH不足.
- 在儿科患者群体中,GH,GHD和睡眠之间的相互作用需要进一步阐明.
研究的目的:
- 系统地审查有关GH和儿童睡眠之间的关系的现有文献.
- 评估GHD对儿科患者睡眠模式的影响.
- 评估GH治疗对儿童GHD睡眠参数的疗效.
主要方法:
- 在Medline/PubMed,Scopus和Web of Science进行了全面的文献搜索,截至2023年4月.
- 搜索词包括"儿童/儿科"",生长激素"",生长激素缺乏症"和"睡眠".
- 从185篇确定文章的数据进行了选,其中9项研究 (六项临床,两项病例系列,一项调查) 在删除重复和排除标准后被纳入.
主要成果:
- 生长激素缺乏 (GHD) 似乎对儿童的睡眠产生不利影响.
- 增长激素 (GH) 治疗仅在一小部分人群中对睡眠参数产生有益影响.
- 可用的数据有限,通常质量不佳,异质和不一致.
结论:
- GHD对儿童的睡眠产生负面影响,尽管确切的机制尚不清楚.
- 在儿科GHD患者中,GH疗法对睡眠有不同的影响.
- 进一步的高质量研究对于了解GHD对儿科睡眠的影响和优化GH治疗策略至关重要.
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