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Updated: Jul 4, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

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通过噪声选:在高通量蛋白质库中准确优先考虑蛋白质-蛋白质结合候选者的计算管道

Arup Mondal1, Bhumika Singh1, Roland H Felkner2

  • 1Department of Chemistry and Quantum Theory Project, University of Florida, Leigh Hall 240, Gainesville, FL.

bioRxiv : the preprint server for biology
|February 8, 2024
PubMed
概括

我们开发了一种新的计算方法,AlphaFold2竞争测试 (AF-CBA),以确定蛋白质结合伙伴及其特定的结合位点. 该工具有助于从大型蛋白质库中选择实验验证的目标.

关键词:
阿尔法折叠是什么意思阿尔法折叠BET BET 在线投注比克拉比克拉是什么意思蛋白质-的相互作用蛋白质与蛋白质的相互作用

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Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates13:49

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相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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