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Updated: Jul 4, 2025

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在压力颗粒内部的TDP-43的内凝体脱混合会产生病态聚合物

Xiao Yan1, David Kuster1,2, Priyesh Mohanty3,2

  • 1Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG); Dresden, Saxony, 01307; Germany.

bioRxiv : the preprint server for biology
|February 8, 2024
PubMed
概括

像ALS这样的神经退行性疾病中的蛋白质聚合需要蛋白质集中在压力颗粒中,并经历氧化压力. 这种双重事件触发了相位的变化,导致了病态的块.

关键词:
这就是ALS.在TDP-43中使用.在凝聚液内进行脱混合.多相冷凝液的使用方法神经退行性疾病的神经退行性疾病阶段分离的阶段分离.蛋白质聚合蛋白质的聚合物压力颗粒是压力颗粒.

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