脑表型预测可以在各种现实世界的数据中生存
Brendan D Adkinson1, Matthew Rosenblatt2, Javid Dadashkarimi3,4
1Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, 06510, USA.
bioRxiv : the preprint server for biology
|February 8, 2024
概括
用于预测精神病治疗的机器学习模型可能会在未协调的数据下失败. 神经成像模型显示出强度的承诺,在多样化,不协调的数据集中展示了可概括的大脑行为关联.
科学领域:
- 神经科学是一个神经科学.
- 机器学习 机器学习
- 精神病学是一个精神病学.
背景情况:
- 基于临床数据的机器学习模型用于精神病治疗预测,通常在不协调的样本中失败.
- 神经成像提供了一个潜在的更强大的替代方案,由于固有的神经生物学信息.
- 现有的神经成像研究往往缺乏跨多样化,不协调的数据集的严格外部验证.
结论:
- 神经成像预测模型有可能在各种现实临床环境中进行强大的精神病治疗结果预测.
- 对非协调数据集进行严格的外部验证对于评估这些模型的真正通用性至关重要.
- 对各种数据集的培训可能会在特定场景中提高预测准确度,为临床翻译铺平道路.
相关概念视频
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Human Genetics
570
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
570
Behavioral Genetics and Its Designs
366
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
366
Genetic Screens
4.9K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.9K


